Summary:
This guide compares REJURAN® and Profhilo, 2 injectable skin boosters with minimal downtime. It explains how each works. REJURAN® is designed to support the skin’s natural repair processes, while Profhilo is intended to improve skin hydration and support skin remodelling. You’ll learn what results to expect, when improvements appear, and how long they last. It also breaks down side effects, recovery, aftercare, treatment schedules, and maintenance. Finally, it helps you decide which option suits your skin goals and whether the 2 can be safely combined.
Injectable skin boosters are no longer just about glow. Today, patients look for treatments that improve skin barrier, hydration, and ageing patterns with minimal downtime. Among the most compared options are REJURAN® vs Profhilo.
Although both aim to enhance skin quality, they work through very different biological mechanisms. Understanding how each treatment works can help you have a more informed discussion with your doctor about which option may be suitable for your skin concerns.
How Each Skin Booster Works
Both treatments are skin boosters, but they work in different ways. One is intended to support the skin’s natural renewal processes, while the other primarily focuses on hydration and skin remodelling.
Polynucleotide Repair: How REJURAN® Works
REJURAN® is formulated with polynucleotides, which are DNA fragments extracted from wild salmon. These are refined using DNA Optimising Technology (DOT™), with studies showing biocompatibility of up to 97%.
So, what does REJURAN® do beneath the skin? When injected into the dermis, these molecules act as a supportive scaffold within the skin. It helps create a favourable environment that supports the skin’s natural recovery process and has been studied for its role in improving overall skin quality.
It is commonly used to address concerns such as:
- Acne scars and enlarged pores
- Skin that appears thinner or more fragile due to ageing or environmental stress
- Redness in sensitive skin types
Hybrid Hyaluronic Boost: Key Benefits of Profhilo
Profhilo uses a patented blend of low- and high-molecular-weight hyaluronic acid. Unlike traditional fillers, it spreads evenly through the skin without adding shape or lift.
After injection, it slowly diffuses to form a deep hydration reservoir in the dermis. This process has been studied for its role in improving skin firmness and elasticity.
Profhilo is often chosen for:
- Global hydration
- Skin laxity
- Loss of elasticity
- Dull, crepey texture
What You Can Expect
While both injectable skin boosters improve overall skin quality, the changes develop in different ways and feel distinct on the skin.
Improvements in Texture, Moisture and Fine Lines
Both treatments improve skin quality, yet the texture changes feel different:
- REJURAN®: May help improve the appearance of enlarged pores, fragile-looking skin and early acne scars. Many patients notice skin that appears calmer and more resilient over time, with fewer reactive flare-ups.
- Profhilo: Focuses more on moisture balance and elasticity. Skin often feels plumper, with improved bounce and light reflection. Improvement in the appearance of fine lines is thought to be related primarily to improved skin hydration.
Many ask, “Which looks more natural?” This is not a simple REJURAN® vs Profhilo scenario. The answer depends on what “natural” means to you personally. Repair versus glow remains the key distinction.
How Soon You’ll See Results—and How Long They Last
- REJURAN®: Delivers gradual improvement because it relies on biological repair. Some patients may notice softer, more radiant-looking skin within 1 week (Individual response varies). Improvements in skin clarity and the appearance of scars may become more noticeable after the 2nd or 3rd session. Results typically last around 9–12 months, although individual response varies.
- Profhilo: May create a mild plumping effect within a few days. Firmer texture and subtle tightening typically appear around 2 weeks after the second treatment. Longevity is comparable, lasting about 9 to 12 months, influenced by lifestyle, sun exposure, and baseline skin quality.
Maintain Your Results with the Right Skincare
Choosing suitable post-treatment skincare may help in maximising and prolonging your results. After REJURAN® or Profhilo, opt for products that calm the skin and reinforce hydration. This helps reduce irritation, supports recovery, and keeps skin resilient between sessions.
Understanding Side Effects & Recovery Time
Both skin boosters are considered minimal downtime aesthetic treatments, though recovery feels different.
REJURAN® Side Effects
REJURAN® is delivered through small injection points across the treatment area.
- Downtime: Small bumps commonly settle within 24–72 hours.
- Sensation: Some mild redness and bruising may occur.
- Aftercare: Avoid heavy makeup for 24 hours and skip rigorous exercises.
What to Expect After a Profhilo Treatment
Profhilo is administered using a technique that limits surface disruption. Many individuals are able to resume their usual activities on the same day.
- Downtime: You may have small lumps at the treated area, but these usually subside within 6–12 hours.
- Sensation: A mild stinging sensation during the injection is normal, but it passes quickly.
- Aftercare: Avoid alcohol and strenuous exercise for 24 hours to minimise the risk of bruising.
Treatment Schedules and Maintenance Plans
Both options work gradually rather than instantly, which is why proper spacing between sessions and regular maintenance are just as important as the treatment itself.
| REJURAN® | Profhilo | |
|---|---|---|
Number of Initial Sessions |
3–4 sessions |
2–3 sessions |
Spacing Between Sessions |
Every 4 weeks |
4 weeks apart |
Biological Purpose |
Supports skin repair and improves skin barrier & overall texture |
Supports skin renewal |
Maintenance Plan |
1 top-up after every 9 to 12 months |
1 top-up every 6–9 months |
Long-Term Skin Goal |
Sustained resilience and improved skin barrier |
Ongoing hydration and subtle firmness |
Who Can Benefit from REJURAN® or Profhilo?
Both treatments are versatile, yet they cater to different skin priorities.
Skin Types, Age Groups and Common Concerns
This comparison helps show which skin booster suits your concerns and the results you are aiming for.
| REJURAN® | Profhilo | |
|---|---|---|
Core Skin Issue |
Structural weakness and impaired repair |
Skin fatigue and dehydration |
Best For |
|
|
Primary Action |
Biological repair and collagen stimulation |
Deep hydration and bio-remodelling |
Skin Result Focus |
Stronger, tougher skin with refined texture |
Bouncier, smoother, more luminous skin |
Ideal For |
Long-term dermal repair rather than quick glow |
Visible freshness without structural filler changes |
Can These Treatments Be Combined?
Yes, REJURAN® can repair the dermal foundation, while Profhilo enhances hydration and elasticity. Treatments are usually spaced out to give the skin sufficient time to respond well to each treatment.
Still Weighing Your Options? Reach Out to Us at DermaRev for Assistance
Unsure which skin booster suits your skin goals or lifestyle needs?
Contact DermaRev at [email protected] for more information, and let us help you find the right option for your skin.
