Summary:
- What It Does: Injectable polynucleotides help improve overall skin quality and support skin rejuvenation, suited for thin, weakened or post-acne skin.
- Downtime: REJURAN® downtime is mild. Patients may experience slight swelling or small bumps, which usually subside within 24-48 hours.
- Protocol: 3–4 sessions, spaced 3–4 weeks apart. Results typically last 9 to 12 months with maintenance.
- How Long REJURAN® lasts: Typically lasts 9 to 12 months with maintenance.
- How It Compares: While lasers and microneedling rely on controlled micro-trauma to trigger a healing response, REJURAN® provides a biological 3D scaffold that actively restores and strengthens the skin's foundation.
- Cost: S$300 to S$800 per session in Singapore.
- Who Should Avoid: Pregnancy, breastfeeding, autoimmune conditions, or clotting disorders. However, these are not absolute contraindications and suitability is assessed by a doctor based on risks and benefits.
Curious about what is REJURAN®? This guide explains REJURAN® polynucleotide treatment in clear, practical terms. You will learn how it supports skin repair from within, what downtime realistically looks like, how long results usually last, and how this injectable compares with lasers or microneedling for skin rejuvenation and acne scar refinement.
How REJURAN® Works Beneath the Skin
REJURAN® is designed to support the skin’s natural repair processes from within. Instead of targeting surface lines, it focuses on strengthening the skin barrier itself. Rather than mechanically filling lines or ablating tissue, this approach is intended to support the skin’s natural renewal processes and strengthen the skin matrix over time.
How DOT™ Polynucleotides (DOT™-PN) Differs from Over-the-Counter PDRN
You may have seen PDRN in calming serums or masks. These products help soothe the skin but work on the surface.
Polynucleotides (PN) are the active ingredient in REJURAN® injectables. PN molecules are longer and larger than DNA fragments derived from wild salmon. DOT™ PN is designed for high biocompatibility and has been studied for its compatibility with human tissue, which contributes to a lower likelihood of immune-related responses.
This allows PN injections to stimulate the skin’s natural reparative capabilities and have been studied for their role in improving overall skin quality, offering longer-lasting improvements compared with over-the-counter PDRN products.
REJURAN® Downtime: What to Expect After Each Session
REJURAN® is associated with relatively short downtime compared with many aesthetic procedures, so results show with little disruption.
Typical REJURAN® Downtime and Recovery Timeline
The milestones below show the usual pace of healing
- After the Treatment: Micro-papules, light warmth and redness.
- Day 1–2: Bumps begin to flatten or fade; mild puffiness and a pink tone may linger. Many feel comfortable returning to work with breathable make-up.
- Day 3: Papules are largely gone. Skin can feel slightly tight as the skin continues its natural recovery process.
- Day 4–7: Surface recovery completes. Subtle improvements in glow and hydration become noticeable.
Normal Signs vs Warning Signs During the Healing Process
Check the table to see which healing signs are normal and when to call your doctor.
| Normal Healing Signs | Warning Signs | |
|---|---|---|
Bumps |
Small bumps that flatten within 24–72 hours. |
Hard lumps that persist beyond 14 days or feel increasingly painful. |
Skin Colour |
Mild pinkness or redness that fades within 2 days; minor bruising. |
Pale or white patches, or a net-like purple pattern (mottling). |
Discomfort Level |
Mild tenderness when the face moves. |
Throbbing, or escalating pain that doesn’t improve with time. |
Surface |
Tiny, dry pin-prick scabs that fall off naturally. |
Presence of pus, yellow discharge, or clusters of blisters or sores. |
Your REJURAN® Aftercare Checklist
Simple habits during the first week help the treatment settle and support the skin’s recovery after treatment.
Skincare, Sunblock and Lifestyle Do’s & Don’ts
Recommended practices for the first 7 days after REJURAN® treatment:
- Cleanse twice daily with a pH-balanced, fragrance-free wash for 3 days.
- Apply REJURAN® Turnover Ampoule and REJURAN® Moisturiser in the morning and at night.
- Use a REJURAN® sunscreen or REJURAN® UV protection cream every morning, including indoors. Top up when necessary.
After completing the full treatment course, results tend to last because REJURAN® is intended to support overall skin quality over time rather than providing only temporary surface improvements.
Activities and skincare to avoid during the same period:
- Facial scrub, peel, or mechanical or chemical exfoliants for 7 days
- Retinoids, hydroxy acids or vitamin C
- Saunas, steam rooms or high-intensity exercise for 48 hours.
Treatment Duration & Clinic Schedules in Singapore
Sessions are spaced to give the skin time to repair and strengthen the skin barrier gradually for more consistent results.
How Many Sessions Singapore Doctors Recommend
Doctors recommend an initial course of 3 to 4 sessions. While some improvements, such as smoother texture and a healthy glow, may be noticeable after a single session, repeated treatments may help optimise treatment outcomes. Over a series of sessions, many patients notice gradual improvements in skin quality, including improved elasticity, refined pore appearance, and stronger overall skin health. Maintenance treatments are usually recommended every 6 to 9 months.
Initial sessions are spaced 1 month apart. This interval matches the skin’s natural turnover cycle of about 28 days. Each treatment builds on the last, allowing polynucleotides to create a favourable physiological condition that stimulates the skin’s natural reparative and restorative capabilities, which may contribute to improvements in skin elasticity over time.
How Long Does REJURAN® Last Before You Need a Top-Up?
After the initial course, results may be maintained with appropriate maintenance treatments because REJURAN® supports the skin’s natural renewal processes over time, rather than creating a temporary surface effect.
- Duration: Firmer, more supple skin typically lasts for approximately 9 to 12 months.
- Maintenance: 1 booster every 9 to 12 months helps maintain results.
Unsure which skincare pairs well with REJURAN® injections?
With the wrong match, you risk irritation or wasted products. Browse our range of products — cleansers, moisturisers and SPF for a gentle post-treatment routine.
Is REJURAN® the Right Choice for You?
REJURAN® suits those who want to strengthen thin skin, soften fine lines, or refine acne scars without laser heat. REJURAN® is safe for all ethnicities and skin shades, providing a versatile option that complements most non-energy-based procedures. If gradual improvements in tone, hydration, and dermal quality appeal to you, this polynucleotide treatment may be a good fit.
Who Should Avoid REJURAN® Injections
REJURAN® is generally well tolerated; however, certain individuals may require extra caution or alternative treatment options. As clinical data in these areas is limited, consultation with a qualified medical professional is recommended before proceeding.
- Pregnancy or breastfeeding
- Active skin infections
- Severe allergies or a history of anaphylaxis
- Autoimmune diseases such as lupus or rheumatoid arthritis
- Blood-clotting disorders or the use of anticoagulant or immunosuppressant drugs
- Pronounced tendency to form keloids or hypertrophic scars.
REJURAN®, Laser or Microneedling: Which Fits Your Goals?
All three treatments stimulate collagen, yet each differs in downtime, pigment safety and the type of concerns it tackles best.
| REJURAN® (PN) | Fractional CO2 Laser | RF Microneedling | |
|---|---|---|---|
Primary Goal |
Skin Quality Support |
Surface Resurfacing |
Deep Tissue Remodelling |
Downtime |
2–3 days (small bumps) |
5–7 days (redness/peeling) |
2–3 days (pinkness) |
Pain Level |
Low to Moderate |
Moderate to High |
Moderate |
Downtime, Pigment Risk and Efficacy
High-intensity lasers can be effective but carry a higher risk of post-inflammatory hyperpigmentation, especially in darker skin tones.
REJURAN® may be considered for individuals with sensitive or pigment-prone skin because it does not rely on heat-based energy. Compared with thermal laser devices, it typically carries a lower risk of pigment disturbance. Lasers offer faster surface smoothing, while REJURAN® delivers gradual improvement by strengthening the skin from within.
What Does Current Research Suggest About REJURAN® for Acne Scars and Fine Lines?
Clinical research points to steady results after a few sessions.
- Collagen & Texture: Increased fibroblast activity and improvements in dermal quality following PN exposure, supporting improvements in skin texture and dermal density.
- Fine Lines & Wrinkles: A 2024 systematic review found reported improvements in wrinkle scores and skin elasticity following PN treatments, and measurable boosts in skin elasticity.
- Atrophic Acne Scars: Some clinical studies have reported reductions in scar depth following PN treatments and improved dermal texture after a short course of treatments.
Need More Details on REJURAN®? Let Our Team at DermaRev Guide You
Curious to learn how REJURAN® could fit your skin goals? Contact DermaRev at [email protected] for personalised advice today!
